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KMID : 0604520060320010007
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Journal of the Society of Cosmetic Scientists of Korea
2006 Volume.32 No. 1 p.7 ~ p.15
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Sprouted Black Rice Oligopeptide Induces Expression of Hyaluronan Synthase in HaCaT Keratinocytes and Improves Skin Elasticity
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Sim Gwan-Sub
Lee Dong-Hwan
Kim Jin-Hwa
An Sung-Kwan
Choi Tae-Boo
Pyo Hyeong-Bae
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Abstract
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In this study, the effect of oligopeptide ($Oligosproutin^{(R)}$) from sprouted black rice was evaluated for possible improvement in skin elasticity. We examined the changes in gene expression on oligopeptide-treated HaCaT cells using DNA microarray analysis. As a result, oligopeptide treatment showed a differential expression ratio of more than 2-fold : 745 genes were activated and 1011 genes were repressed. One of the most interesting findings is a 2-fold increase in hyaluronan synthase 2 (HAS 2) gene expression by oligopeptide. We also found that oligopeptide increased cell proliferation, HAS2 mRNA expression and intracellular ROS scavenging activity in HaCaT cells. A human clinical study which oil-in-water emulsion with oligopeptide was topically applied showed significant increase in skin elasticity. These results suggest that the sprouted black rice oligopeptide (Oligosproutin^{(R)}) can be effective anti-aging ingredient for cosmetics.
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KEYWORD
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sprouted black rice, microarray, oligopeptide, hyaluronan synthase, elasticity
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